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This type of biochemicalresearch may contribute to an understanding of fundamental proteinasebiochemistry and cell biology. The new knowledge may have potentialapplications to help patients with cancer, stroke, arthritis, diabetes,obesity, and cardiovascular diseases. Dr. Sang's laboratory is interested in proteinchemistry and enzymology of metalloproteinases and their natural and syntheticinhibitors. The biological and pathological roles of these enzymes andinhibitors are investigated in the regulation of adult mesenchymal stem celldifferentiation and fate. The classical biochemistry is combined with molecularbiology, cell biology, material science, medicinal chemistry, and biomedicalsciences. The research team isfocusing on the studies of the biochemical mechanisms of zymogen activation,substrate specificities, the inhibition kinetics, and the structure functionrelationships of the proteinases and their inhibitors. These synthetic smallmolecular enzyme inhibitors may be further developed to become potentialcandidates for therapeutics for treating cancer invasion, metastasis, stroke,and obesity. Sang research team is exploring the biochemicalbasis and molecular mechanisms of human cancer cell progression, invasion, andmetastasis. Matrix metalloproteinases MMPs or matrixins are a family ofendopeptidases that require zinc for catalysis and calcium for protein folding. Because of their abilities to dissolve connective tissue barrier proteins suchas collagens, fibronectin, and laminins, matrixins are one of the mostimportant classes of molecules used by invading cells to facilitate invasive growthand spread.
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Others contend that the development of the imagination is critical not only to our individual development but also to our collective development. Jung 1933, already cognizant of the pressures of our modern life, warns us not to abandon our species hard fought accomplishments in developing our spiritual life. : 125. The consequences of losing or not developing our imaginative capacities can have serious and as yet unforeseen repercussions and, as Jung warns us, our collective accomplishments can be turned back. In summary, the imagination is unique to humans, and it is critical for our learning and for childrens proper intellectual development. It is also a key part of what makes us human. In addition, the imagination is a learned ability, one which is not yet present in young children we can conclude from Piagets theory on make believe play that the imagination develops along with make believe play. It is originally derived from the basic senses, works on the material that is present in the brain and bridges the gap between the self and the object of desire, as well as the time from the present to the future. The development of the imagination also appears necessary in order to be able to distinguish between the imagined and the real. In children, the imagination develops and expresses in imaginative play and creative imagination. The emphasis is on the novel reshaping of already familiar images and experiences.
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Pearce 1985: 63 states that bstract imagery is not present to the senses; it must be created from within. We must then process that imagery, transfer it into images available to the senses out there. If we cannot, we have no imagination, and if we have no imagination we are automatically grounded in sensory motor imagery. When the mind is bombarded with sensory input from an artificial medium, there is no place for acquiring and manipulating abstract imagery. There is no creation of images from within, and therefore no imagination. In his warning to us about the dangerous aspects of childrens exposure to artificial media, Latham 2003: iv concludes that young childrens spontaneous imaginative capabilities may be neurologically foreclosed and become increasingly impoverished as exposure to screen based electronic entertainment rises. The internal process of imagination is replaced by the outside exposure to the artificial media. Kline 1989 summarizes this shift as one in which marketing, rather than entertainment, considerations dominate the design of childrens characters, the fictions in which they appear, and hence the way children play ibid. At the same time, lay, the most important modality of childhood learning is thus colonized by marketing objectives making the imagination the organ of corporate desire. The consumption ethos has become the vortex of childrens culture ibid. emphasis added.
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Ct. 484, 76 L. Ed. 984, 88 A. L. R. Rentoul. 'Cinderella retold for Australians: Part II',The New Idea, Sydney, December 1903. Illustrations by I. S. Rentoul, text by A.
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Molly, Alice, and Fleur were busy altering the dresses to fit the girls, while Molly also worked to finish Ginny's dress. A few times, Molly bemoaned the small ceremony. She wanted a huge event, with all their family and friends, but Harry and Ginny put their foot down, and insisted. They didn't want a large ceremony with tons of relatives they barely knew. It was just a formality, really. They were already married. Besides, the larger the event, the more chance there was of someone managing to sneak in. They didn't want their wedding to turn into a media circus. Molly understood their thought process, she just wanted to show off her son in law to everyone. It had nothing to do with Harry being the Boy Who Lived, she was simply proud of the man he was. He was kind, and thoughtful, caring, and so good to Ginny.